Written in English
|The Physical Object|
|Pagination||1 v., 140 leaves|
|Number of Pages||140|
The nonlinear pharmacokinetics in pregnant rabbits present already between the 5 and 15 mg/kg/day doses in this study indicates that the metabolism and/or clearance of afidopyropen was distinctly saturated at the 16 and 32 mg/kg/day doses in the definitive afidopyropen rabbit developmental toxicity study (0, 8, 16, 32 mg/kg/day). Coronal view of rabbit laying in dorsal recumbency showing regions of interest (ROIs) selected for dynamic contrast-enhanced magnetic resonance imaging pharmacokinetic parameter analysis. A, ROI (outlined in blue) for time points 1 and 2 was the incisor pulp from the irradiated (left) side of the : Stacey L. Piotrowski, Lindsay Wilson, Kiersten L. Maldonado, Ramesh Tailor, Lori R. Hill, James A. B. In a Latin square design, nine New Zealand white male rabbits ( – kg) each received intravenous indocyanine green (ICG) in doses of , , and 25 mg/kg. A period of 4 weeks separated con Cited by: Analysis of Drug Distribution in Rabbit Ocular Tissues. Rabbits were anesthetized as described above and euthanized at various time points postimplantation (1, 2, 4, and 8 weeks) by intravenous injection of 2 mmol/kg potassium chloride into the marginal ear vein. The ocular globe was enucleated immediately after euthanasia.
2 days ago Epizootic rabbit enteropathy (ERE) affects young rabbits and represents 32% of the enteropathies in rabbit production farms in Mexico. The etiology of this syndrome has not been clarified yet. A metataxonomic and histopathology study of ERE was carried out to compare the gastrointestinal microbiota and histopathological lesions of healthy and positive-ERE rabbits. The mechanisms of drug clearance from the aqueous humor are poorly defined. In this study, a cocktail approach was used to simultaneously determine the pharmacokinetics of three β-blocker agents after intracameral (ic) injection into the rabbit eyes. Aqueous humor samples were collected and analyzed using LC–MS/MS to determine drug concentrations. Pharmacokinetic parameters were obtained. Particulate-phase sulfaquinoxaline will be removed from the atmosphere by wet or dry deposition. Sulfaquinoxaline absorbs light at wavelengths > nm (UV max = nm) and therefore may be susceptible to direct photolysis by sunlight. If released to soil, sulfaquinoxaline is expected to have moderate mobility based upon an estimated Koc of The non-compartmental pharmacokinetic analysis was performed in accordance with reference text books . Further details and equations are presented in Additional file 1.
Transport of biologicals from the vitreous to the anterior chamber has been quantitated in many experimental rabbit studies [14,15,16,17,18]. Furthermore, this has been modeled recently with physiologically based pharmacokinetic (PBPK) and finite element models [8,19]. Since PBPK and finite element models require specialized expertise in. Robert F Storey, Paul A Gurbel, Jurrien ten Berg, Corine Bernaud, George D Dangas, Jean-Marie Frenoux, Diana A Gorog, Abdel Hmissi, Vijay Kunadian, Stefan K James, Jean-Francois Tanguay, Henry Tran, Dietmar Trenk, Mike Ufer, Pim Van der Harst, Arnoud W J Van't Hof, Dominick J Angiolillo, Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of . Relationship – Dynamics and Kinetics Dosage Regimen Concentration in Plasma Concentration at the site of action Absorption Distribution Metabolism Excretion Pharmacokinetics Pharmacodynamics Effect 4. The Pharmacokinetic Process 5. The Pharmacokinetic Process 6. Biological Membrane - image 7. Pharmacokinetic Analysis. For pharmacokinetic data analysis, the bevacizumab concentration-time data in various ocular tissues and plasma were analyzed using Phoenix WinNonlin (Pharsight - A Certara Company, St. Louis, MO) by fitting the data to the extravascular input model, and the non-compartmental parameters of the bevacizumab elimination were estimated .